Preheat the oven to 375 degrees F (190 degrees C).

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Spray cauliflower florets with cooking spray and season with salt and pepper; place on a baking sheet.

Roast in the preheated oven for 30 minutes.

Meanwhile, heat half-and-half in a saucepan over medium-low heat. Add Mexican, Cheddar, and cream cheeses slowly, stirring to combine, until melted.

Butter an 8×10-inch baking dish.

Mix roasted cauliflower with cheese sauce. Transfer to the prepared dish.

Bake in the preheated oven until bubbly, about 15 minutes.